Discovery of Tumor Suppressor Gene Function
نویسندگان
چکیده
منابع مشابه
Gain-of-function mutations in the tumor suppressor gene p53.
The tumor suppressor protein p53 is a multifunctional transcription factor involved in the control of cell cycle progression, DNA integrity, and cell survival. p53 is mutated in half of all tumors and has a wide spectrum of mutation types. p53 mutants show different degrees of dominance over coexpressed wild-type p53, and loss of the wild-type p53 allele has been observed frequently. Several p5...
متن کاملNF1 Tumor Suppressor Gene Function Narrowing the GAP
tumor suppressor gene, loss of heterozygosity (LOH) or Introduction “second-hit” somatic mutations in the inherited wildTumor suppressor genes are typically identified through type allele have been detected in some tumor types in their association with a familial cancer syndrome. As a NF1 patients (Xu et al., 1992; Legius et al., 1993; Shannon result, information regarding the normal function o...
متن کاملMutation Analysis of TP53 Tumor Suppressor Gene in Colorectal Cancer in Patients from Iran (Kerman Province)
Objective(s) P53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. The aim of this study was to reveal mutations of TP53 in colorectal cancer in Kerman province. Materials and Methods A total of Forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage IIIA, were selected. Three exons 5,...
متن کاملDiscovery of Mieap‐regulated mitochondrial quality control as a new function of tumor suppressor p53
The tumor suppressor p53 gene is frequently mutated in human cancers, and the p53 protein suppresses cancer. However, the mechanism behind the p53-mediated tumor suppression is still unclear. Recently, the mitochondria-eating protein (Mieap) was identified as a p53-inducible protein. Mieap induces the accumulation of lysosomal proteins within mitochondria (Mieap-induced accumulation of lysosome...
متن کاملStructure-Function of the Tumor Suppressor BRCA1
BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity of BRCA1 and mediates interactions between BRCA1 and other proteins. BRCA1 ubiquitinates several p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Biology Teacher
سال: 1995
ISSN: 0002-7685
DOI: 10.2307/4449970